PROGRAM

                                                 

AMPK 2016 Programme.doc

Day 0 - Friday 11th November

09:00-21:00           Registration

17:30                      Drinks reception

18:30                      Dinner

Day 1 - Saturday 12th November

07:30-09:00            Breakfast

09:00-09:15            Welcome and introductory remarks

                               (Sheng-Cai Lin, David Carling)

09:15-10:15            Opening Keynote Talk (Chair: Grahame Hardie)

                               “Targeting energy stress and reactive oxygen stress in cancer cells”

                               Lewis Cantley (Weill Cornell Medical College, USA)

Session 1: AMPK Structure and regulation (Chair: David Carling)

10:15-10:45            “Binding from top and bottom: synthetic activators employ distinct sites to achieve AMPK isoform selectivity”

                               Ravi Kurumbail (Pfizer, USA)

10:45-11:15            “Structural aspects of AMPK signalling regulation by drugs and metabolites”

                               Bruce Kemp (St. Vincent’s Institute of Medical Research, Australia)

11:15-11:45            Group photo & Coffee Break

11:45-12:15            “Structural and biophysical analysis of AMPK”

                               Karsten Melcher (Van Andel Research Institute, USA)

12:15-12:45            “Regulation of AMPK-related kinases”

                               Jiawei Wu (Tsinghua University, China)

12:45-13:00            Short Talk:“Monitoring ligand binding and associated conformational dynamics of AMPK”

                               Matt Sanders (Francis Crick Institute, UK; now at Nestle Institute of Health Sciences, Switzerland)

13:00-14:00            Lunch

Session 2: Nutrient sensing (Chair: Bruce Kemp)

14:00-14:30            “AMPK senses glucose via a non-canonical pathway”

                               Grahame Hardie (University of Dundee, Scotland, UK)

14:30-15:00            “Mechanism for glucose starvation-induced AMPK activation”

                               Sheng-Cai Lin (Xiamen University, China)

 15:00-15:15            Short Talk: “Lysosomalamino acid sensing complex mediates metformin induced AAK-2 activation and longevity”

                                Jie Chen (Beijing University, China)

 15:15-15:30            Short Talk: “Environmental control of cell growth and proliferation”

                                Janni Petersen (Flinders University, Australia)

15:30-16:00            Tea/coffee

16:00-18:30            POSTER SESSION I

19:00                      Dinner

Day 2 - Sunday 13th November

07:30-09:00     Breakfast

Session 3: AMPK function in vivo (Chair: Larry Young)

09:00-09:30            “A genetic model for activation of AMPK in vivo

                               David Carling (MRC Clinical Sciences Centre, Imperial College London, UK)

09:30-10:00            “Adiponectin and adiponectin receptors: Roles in obesity-linked diseases and novel therapeutic strategy”                         

                               Takashi Kadowaki (University of Tokyo, Japan)

10:00-10:15            Short Talk: “The AMPK-TBC1D1-Rab8a axis regulates IGF1 secretion”

                               Shuai Chen (Nanjing University, China)

10:15-10:30            Short Talk: “Role of the type 2 diabetes GWAS gene TCF7L2 in LKB1-mediated regulation of insulin secretion in the murine beta cell”

                               Guy Rutter (Imperial College London, UK)

10:30-11:00            Tea/coffee

11:00-11:30            “The systemic consequences of long-term gamma-2 AMPK activation”

                               ArashYavari (University of Oxford, UK)

11:30-12:00            “AMPKamma-2 mutations, WPW syndrome, and effects on metabolism in mice”

                                Hong-Ping Guan (Merck, USA)

12:00-12:15            Short Talk: “AMPK, a key element for stem cell differentiation”

                               Luc Bertrand (Universitécatholique de Louvain, Belgium)

12:15-12:30            Short Talk: “The role of AMP-activated protein kinase in the anti-contractile effect of perivascular adipose tissue”

                               Ian Salt (University of Glasgow, Scotland, UK)

12:30-13:30            Lunch

Session 4: AMPK and metabolism (Chair: Neil Ruderman)

13:30-14:00            “AMPK-dependent metabolic rewiring”

                               Reuben Shaw (Salk Institute, USA)

14:00-14:30            “AMP-/ZMP-dependent regulation of hepatic gluconeogenesis”

                               Kei Sakamoto (Nestle Institute of Health Sciences, Switzerland)

14:30-15:00            “Burning the fat: when lipid droplets meet mitochondria”

                               Marta Bosch (Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain)

15:00-15:30            “AMPK and mTORC2 differentially regulate muscle triglyceride content via Perilipin 3”

                               Erik Richter (University of Copenhagen, Denmark)

15:30-16:00            Tea/coffee

16:00-18:30            POSTER SESSION II

19:00                      Dinner

Day 3 - Monday 14th November

07:30-09:00     Breakfast

Session 5: Physiological roles in different tissues (Chair: Mark Rider)

09:00-09:30            “AMPK in the intestinal epithelium: insights from KO mouse models”

                                Benoit Viollet (Institut Cochin, France)

09:30-10:00            “AMPK and bariatric surgery in very obese humans”

                                Neil Ruderman (Boston University, USA)

10:00-10:30            “AMPK regulation of lipid metabolism”

                                Greg Steinberg (McMaster University, Canada)

10:30-10:45            Short Talk: “Lkb1-AMPK-mTOR axis controls brown fat mass in mice”

                                Shihuan Kuang (Purdue University, USA)

10:45-11:15            Tea/coffee

11:15-11:45            “AMPK: Novel Biological Actions in the Heart”

                                Lawrence Young (Yale School of Medicine, USA)

11:45-12:15            “AMPK in muscle glucose metabolism”

                               Jörgen Wojtaszewski (University of Copenhagen, Denmark)

12:15-12:45            “Hypothalamic AMPK: a canonical regulator of energy balance”

                               Miguel Lopez (Universidad de Santiago de Compostela, Spain)

12:45-14:00            Lunch

14:30-18:30           Afternoon free for excursions

19:00                      Dinner 

Day 4– Tuesday 15th November

07:30-09:00     Breakfast

Session 6: Crosstalk with other pathways (Chair: Kei Sakamoto)

09:00-09:30            “AMPK in neurons: at the helm during difficult times”

                                Richard Roy (McGill University, Canada)

09:30-10:00            “AMPK activation antagonizes hepatic glucagon signalling”

                                Mark Rider (de Duve Institute, Université catholique de Louvain, Belgium)

10:00-10:15            Short Talk: “Role of AMPK, and its regulation by insulin, in the hormonal control of adipocyte metabolism”

                                Olga Göransson (Lund University, Sweden)

10:15-10:30            Short Talk: “The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs through phosphorylation of β1-Ser108”

                               Jon Oakhill (St. Vincent’s Institute, University of Melbourne, Australia)

10:30-11:00            Tea/coffee

11:00-11:30            “Regulation of Hippo-YAP pathway by energy stress and cancer mutations”

                                Kun-liang Guan (University of California San Diego, USA)

11:30-12:00            “Novel AMPK-dependent functions of FLCN”

                                Arnim Pause (McGill University, Canada)

12:00-12:15            Short Talk: “CDK4 controls fatty acid oxidation via the repression of AMPK activity”

                                Isabel Lopez-Mejia (Université de Lausanne, Switzerland)

12:15-12:30            Short Talk: “Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a Thr85Ser mutation associated with anxiety and bipolar disorder”

                               John Scott (St. Vincent’s Institute, University of Melbourne, Australia)

12:30-12:45            Short Talk: “Uncoupling of the Mitogenic and Metabolic Functions of FGF1”

                               Zhifeng Huang (Wenzhou Medical University, China)

12:45-13:45            Lunch

Session 7: AMPK and cancer (Chair: Grahame Hardie)

13:45-14:15            “LKB1-AMPK signalling at the intersection of inflammation and cancer”

                                 Russell Jones (McGill University, Canada)

14:15-14:45            “Degradation of AMPK by a cancer-specific ubiquitin ligase”

                                 Ryan Potts (St. Jude Children's Research Hospital, USA)

14:45-15:00            Short Talk: “AMP Kinase: evolving lessons about its context-dependent opposite roles in cancer”

                                 Biplab Dasgupta (Cincinnati Childrens Hospital Medical Center, USA)

15:00-15:30            Tea/coffee 

15:30-16:30            Closing Keynote Talk (Chair: Grahame Hardie)

                               “mTORsignaling in growth and metabolism”

                                 Michael Hall (Biozentrum, University of Basel, Switzerland)

16:30-16:45            Closing remarks

                                Sheng-Cai Lin, Dave Carling and Grahame Hardie.

19:00-late               Closing Banquet and Party

Day 5 – Wednesday 16th November

07:30-09:00     Breakfast

Departure